#EUTHYROID SICK SYNDROME MAYO CLINIC FREE#

Common causes of endogenous subclinical hyperthyroidism include Graves disease, autonomous functioning thyroid adenoma, and multinodular toxic goiter. Subclinical hyperthyroidism may result from endogenous overproduction of thyroid hormone, administration of thyroid hormone to suppress malignancy, or excessive thyroid hormone replacement therapy in patients with hypothyroidism. The American Thyroid Association and the American Association of Clinical Endocrinologists recommend treating patients with thyroid-stimulating hormone levels less than 0.1 mIU per L if they are older than 65 years or have comorbidities such as heart disease or osteoporosis. Preventive Services Task Force found insufficient evidence to assess the balance of benefits and harms of screening for thyroid dysfunction in asymptomatic persons. A possible association between subclinical hyperthyroidism and quality-of-life parameters and cognition is controversial.

However, the effectiveness of treatment in preventing these conditions is unclear. Subclinical hyperthyroidism is associated with an increased risk of atrial fibrillation and heart failure in older adults, increased cardiovascular and all-cause mortality, and decreased bone mineral density and increased bone fracture risk in postmenopausal women.

The rate of progression to overt hyperthyroidism is higher in persons with thyroid-stimulating hormone levels less than 0.1 mIU per L than in persons with low but detectable thyroid-stimulating hormone levels. The prevalence of subclinical hyperthyroidism in the general population is about 1% to 2% however, it may be higher in iodine-deficient areas. It can be caused by increased endogenous production of thyroid hormone (e.g., in Graves disease, toxic nodular goiter, or transient thyroiditis), by administration of thyroid hormone to treat malignant thyroid disease, or by unintentional excessive replacement therapy.

#EUTHYROID SICK SYNDROME MAYO CLINIC FREE#

Subclinical hyperthyroidism is defined by a low or undetectable serum thyroid-stimulating hormone level, with normal free thyroxine and total or free triiodothyronine levels.

Euthyroid sick syndrome mayo clinic